毕启瑞 副研究员

毕启瑞 

博士，副研究员，硕士研究生导师。上海市药学会青年委员

上海市中医药国际标准化研究院。

主要从事动物药药效物质发现及肽类新药开发研究。以第一作者或共同通讯作者在JPharm Anal、FoodChem、Phytomedicine等国际期刊发表Sci论文30余篇，授权专利一项；主持国家自然青年基金、省自然青年基金等项目3项，参与国家重点项目、科技部新药重大专项等4项。

研究方向：

1）动物药效应物质发现研究

2）肽类新药开发研究

主持项目：

1）国家自然科学基金青年基金项目，基于特征肽类成分的动物药整体质量评价体系研究：以地龙为例，81803716

2）江苏省青年基金，基于特征肽类成分多指标定量分析及特征图谱相结合的动物药质量评价方法研究，BK20170738

3）江苏省博士后科研资助计划A类，一种用于动物药地龙抗炎活性肽类成分发现的新策略，126002003

主要成果：

1) Xiaoxiao Luo ^#, QiruiBi^#, Dongdong Huang, Yun Li, Changliang Yao, Jingxian Zhang, Wenlong Wei, JiayuanLi, Zhenwei Li, Jianqing Zhang, Shen Ji*, Yurong Wang *, Dean Guo*. Characterization ofnatural peptides in Pheretima by integrating proteogenomics and label-free peptidomics.Journal of Pharmaceutical Analysis, 2023, 13(9): 1070-1079.

2) Yelin Ding ^#, QiruiBi^#, Dongdong Huang, Jingmei Liao, Lin Yang, Xiaoxiao Luo, Peilei Yang, Yun Li,Changliang Yao, Wenlong Wei, Jianqing Zhang, Jiayuan Li, Yong Huang, De-an Guo*. A novelintegrated automatic strategy for amino acid composition analysis of seeds from 67 species.Food Chemistry, 2023: 136670.

3) Cuicui Wang ^#, QiruiBi^#, Dongdong Huang, Shifei Wu, Min Gao, Yun Li, Longsheng Xing, Shuai Yao, DeanGuo*. Identification of Pinelliae Rhizoma and its counterfeit species based onenzymatic signature peptides from toxic proteins. Phytomedicine, 2022,107:154451.

4) Peilei Yang ^#, QiruiBi^#, Yun Li, Jingmei Liao, Yelin Ding, Dongdong Huang, Xiaoxiao Luo, Yong Huang,Changliang Yao, Jianqing Zhang, Wenlong Wei, Zhenwei Li, Jiang Meng *, De-an Guo*.Identification of five gelatins based on marker peptides from type I collagen by massspectrum in multiple reaction monitoring mode. Journal of Agricultural and Food Chemistry,2023, 71(14): 5851-5860.

5) Dongdong Huang ^#, Xiaoxiao Luo^#, Qirui Bi^#, Yelin Ding, Yun Li, Cuicui Wang, Min Gao, Yong Huang,Changliang Yao, Jianqing Zhang, Wenlong Wei, Yurong Wang *, Dean Guo*. A pseudotargetedpeptidomics strategy for screening natural signature peptides in animal-derived drugs:Taking Pheretima as a case. Arabian Journal of Chemistry, 2023, 16(8): 104980.