魏文龙 副研究员

魏文龙 

中国药科大学理学博士，上海市中医药国际标准化研究院副研究员，硕士研究生导师。主要从事中药分析、代谢和药效物质及靶标研究，主持国家自然科学基金青年基金项目（C类）和上海市科学技术委员会扬帆计划项目，以第一/共一作者发表SCI论文20余篇，参与授权专利1项。在《FoodChemistry》、《Journalof Pharmaceutical Analysis》、《Phytomedicine》等杂志发表相关论文。完成上海市中药配方颗粒质量标准7项。参与国家自然科学基金专项项目1项、国家自然科学基金重点项目2项、国家自然科学基金面上项目1项。

研究方向：

1）中药作用机制及靶标研究

2）中药物质基础和体内代谢研究

主持项目：

1.国家自然科学基金青年基金项目，基于“多模式质谱-关键成分群-红外定量模型”的多基原近缘中药质量评价方法研究，NO.82104385

2.上海市科学技术委员会扬帆计划，传统中药中抗阿尔茨海默症活性成分的系统筛选与机制研究，NO.21YF1455800

主要成果：

第一或共一作者发表的论文

1. WenlongWei#, Saiyi Ye#, QiuyiWen, Shuai Yao, Huiting Ou, Chunxiang Liu, Qirui Bi, Hua Qu, Erwei Hao, ChunYao*, Jianqing Zhang*, Dean Guo*. A novel and practical strategy forcomprehensive differentiation and profiling of eight Curcumae varieties andtheir counterfeit from the Chinese market. Food Chemistry 2025.

2. Yun-ShuHu#, Jian-QingZhang#, WenlongWei#et al. ComprehensiveHRMS Screening and Risk Assessments of Aristolochic Acid Analogues inAsariRadix et Rhizoma andRelated Commercial Health Products. Journal of Agricultural and Food Chemistry2024.

3. WenlongWei#, ZhenweiLi#, ShiweiLi# et al.Fingerprint profiling and gut microbiota regulation of polysaccharides fromFritillaria species. International Journalof Biological Macromolecules2023.

4. WenlongWei#, HaojvLi# et al. Anintegrated strategy for comprehensive characterization of metabolites andmetabolic profiles of bufadienolides from Venenum Bufonis in rats. Journal ofPharmaceutical Analysis 2022.

5. WenlongWei#, YalingAn# et al.Simultaneous determination of resibufogenin and its eight metabolites in ratplasma by LC-MS/MS for metabolic profiles and pharmacokinetic study.Phytomedicine 2019.

6. WenlongWei#, YalingAn# et al.Quantitative analysis of fourteen bufadienolides in Venenum Bufonis crude drugand its Chinese patent medicines by ultra-high performance liquid chromatographycoupled with tandem mass spectrometry. Journal ofEthnopharmacology 2020.

7. WenlongWei#, JinjunHou# et al. Ahigh-efficiency strategy integrating offline two-dimensional separation and datapost-processing with dereplication: Characterization of bufadienolides inVenenumBufonis as a casestudy. Journal ofChromatography A 2019.

8. Haojv Li#, WenlongWei# et al. Anenhanced strategy integrating offline two-dimensional separation with dataindependent acquisition mode and deconvolution: Characterization of metabolitesof Uncariarhynchophylla in rat plasmaas a case. Journal ofChromatography B 2021.

9. WenlongWei#, Shi-Fei,Wu# et al. Chemicalprofiling of Huashi Baidu prescription, an effective anti-COVID-19 TCM formula,by UPLC-Q-TOF/MS. Chinese Journal ofNatural Medicines 2021.

10. Yaling An#, WenlongWei#et al. An enhancedstrategy integrating offline superimposed two-dimensional separation with massdefect filter and diagnostic ion filter: Comprehensive characterization ofsteroid alkaloids in Fritillariae PallidifloraeBulbus as a casestudy. Journal ofChromatography A 2021.

11. WenlongWei#, ZhenweiLi#et al. The inhibitoryeffect of 225 frequently-used traditional Chinese medicines for CYP3A4 metabolicenzyme by isoform-specific probe. Fitoterapia 2021.

12. WenlongWei#, ZhenweiLi#et al. Exploration oftissue distribution of ginsenoside Rg1 by LC-MS/MS and nanospray desorptionelectrospray ionization mass spectrometry.Journal ofPharmaceutical and Biomedical Analysis 2021.

13. ZhenweiLi#, WenlongWei#et al. A systematicstrategy integrating solid-phase extraction, full scan range splitting, massdefect filter and precursor ion list for comprehensive metabolite profiling ofDanqi Tongmai tablet in rats. Journal ofPharmaceutical and Biomedical Analysis 2021.

14. WenlongWei#, Shi-FeiWu# et al.Exploration of bioactive constituents and immunoregulatory mechanisms of aHanshi-Yufei formulation for treating COVID-19. World Journal ofTraditional Chinese Medicine 2021.

15. Haojv Li#, WenlongWei# et al.Systematic comparison of metabolic differences of Uncaria rhynchophylla in rat,mouse, dog, pig, monkey and human liver microsomes. Analytical andBioanalytical Chemistry 2020.

16. WenlongWei#,Haojv Li# et al.Simultaneous determination of cinobufagin and its five metabolites in rat plasmaby LC-MS/MS for characterization of metabolic profiles and pharmacokineticstudy. AnalyticalMethods 2019.

17. WenlongWei#, Yang Yu#et al. SimultaneousDetermination of Bufalin and Its Nine Metabolites in Rat Plasma forCharacterization of Metabolic Profiles and Pharmacokinetic Study by LC-MS/MS.Molecules2019.

18. WenlongWei#, JinjunHou#et al. Venenumbufonis: An overview of its traditional use, natural product chemistry,pharmacology, pharmacokinetics and toxicology. Journal ofEthnopharmacology 2019.

19. WenlongWei#, XiaWang#, JinjunHou#et al. Implementationof a Single Quadrupole Mass Spectrometer for Fingerprint Analysis: Venenumbufonis as a Case Study. Molecules2018.

20. Wenlong Wei#et al.Discrimination ofProducing Areas of Astragalusmembranaceus UsingElectronic Nose and UHPLC-PDA Combined with Chemometrics. Czech Journal of FoodSciences 2017

21. WenlongWei#et al.Angelicasinensis in China-Areview of botanical profile, ethnopharmacology, phytochemistry and chemicalanalysis. Journal ofEthnopharmacology 2016.

22. WenlongWei#et al.SimultaneousDetermination of Ferulic Acid and Phthalides of AngelicaSinensis Based onUPLC-Q-TOF/MS. Molecules 2015.